YEO LAB
YEO LAB
Cellular and Molecular Medicine
Gene Yeo received his B.S. in Chemical Engineering and B.A. in Economics from the University of Illinois, Urbana-Champaign in 1998 before returning to Singapore to serve in the military as a Naval Officer until 2000. In 2001, Gene returned to the United States for graduate school, and completed his Ph.D. in Computational Neuroscience in 2004 from the Massachusetts Institute of Technology under the guidance of Dr. Tomaso Poggio and Dr. Christopher Burge. Using comparative genomics and statistical learning theory Gene had pioneered new computational approaches to attack the problem of splicing and splicing-mediated regulation (Graduate Thesis PDF). In 2005 Gene was appointed the first Junior Fellow at the Crick-Jacobs Center at the Salk Institute under the mentorship of Dr. Fred Gage and Dr. Sean Eddy. Gene’s work as a Fellow encompassed neurogenesis with Dr. Fred Gage; small RNA biology in stem cells in collaboration with Dr Phillip Sharp and in planarians in collaboration with Dr. Brent Graveley; alternative splicing and RNA binding protein-RNA interaction maps in stem cells; and new molecular and analysis tools in conjunction with high-throughput sequencing with Dr Xiang-dong Fu. In Oct 2008, Gene was appointed an Assistant Professor in the Department of Cellular and Molecular Medicine, UCSD. Currently, Gene’s research is focused on (i) the roles of RNA binding proteins in human genetic and infectious diseases, (ii) microRNA pathways in the specification of pluripotency and fate choice, (iii) the systematic elucidation of RNA binding protein-RNA maps in cancer cells, and (iv) engineering approaches to stem cell fate choices.
Gene Yeo, Ph.D.
PRINCIPAL INVESTIGATOR
Assistant Professor, UCSD
email geneyeo at ucsd dot edu
Ph.D., Computational Neuroscience, MIT, 2005
B.S., Chemical Engineering, University of Illinois, Urbana-Champaign 1998
B.A., Economics, University of Illinois, Urbana-Champaign1998
Degrees
Summary
Publications
The EJC factor eIFAIII modulates synaptic strength and neuronal protein expression. Giorgi. C, Yeo, G, Stone, ME, Katz, DB, Burge C, Turrigiano, C, Moore, MJ. Cell, 2007. [PMID: 17632064]
Inference of splicing regulatory activities by sequence neighborhood analysis. Stadler MB, Shomron N, Yeo GW, Schneider, A, Xiao, X, Burge CB PLoS Genetics, 2006 [PMID: 17121466]
Combinatorial code for splicing silencing: UAGG and GGGG motifs. Han, K, Yeo, G, An, P, Burge, CB and Grabowski, P. PLoS Biology. 2005. [PMID: 15828859]
Identification and analysis of alternative splicing events conserved in human and mouse. Yeo, G*, Van Nostrand, E, Holste, D, Poggio, T and Burge, CB*. PNAS, 2005 (*co-corresponding). [PMID: 15708978]
Systematic identification and analysis of exonic splicing silencers. Wang, Z, Rolish, ME, Yeo, G, Tung,V, Mawson, M, and Burge C.B. Cell, 2004. [PMID: 15607979]
Variation in alternative splicing across human tissues. Yeo, G, Holste D, Kreiman, G, and Burge, C.B. Genome Biology, 2004. [PMID: 15461793]
Variation in the splicing regulatory elements and their organization in vertebrate genomes. Yeo, G, Hoon S, Venkatesh, B, and Burge, C.B. PNAS, 2004. [PMID: 15505203]
RESCUE-ESE identifies candidate exonic splicing enhancers in vertebrate exons. Fairbrother WG, Yeo, G, Yeh, R, Goldstein, P, Mawson, M, Sharp PA, Burge CB. Nucleic Acids Res. 2004. [PMID: 15215377]
Maximum entropy modeling of short sequence motifs with applications to RNA splicing signals. Yeo, G, and Burge, C., Journal of Computational Biology, 2004. [PDF]
Non-classical splicing mutations in the coding and non-coding regions of the ATM gene: a comparison of cDNA with maximum entropy estimates of splice junction strengths. Eng, L, Coutinho G, Nahas, S, Yeo, G, Tanouye, R, Drk, T, Burge, C.B, and Gatti, R.A. Human Mutation, 23(1), 67-76, 2004. [PMID:14695534]
Regularized Least-squares Classification. Rifkin, R, Yeo, G and Poggio, T. Advances in Learning Theory: Methods, Model and Applications, NATO Science Series III: Computer and System Sciences, Vol. 190, ISO Press, Amsterdam 2003. [PDF]
